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2014年白小姐铁算盘资料【唯一授权官网】】】】】

  2016-01-20 13:52  中国润滑油信息网
2014年白小姐铁算盘资料【唯一授权官网】】】】】

IFIT5 potentiates anti-viral response through enhancing innate immune signaling pathways

Bianhong Zhang, Xinyi Liu, Wei Chen and Liang Chen

Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, Shanghai , China

Acta Biochim Biophys Sin 2013, 45: 867–874; doi: 10.1093/abbs/gmt088

Humans have a distinct combination of IFIT (IFN-induced protein with tetratricopeptide repeats) family orthologs, including IFIT1 (ISG56), IFIT2 (ISG54), IFIT3 (ISG60), and IFIT5 (ISG58). The function of IFIT1/IFIT2/IFIT3 has been intensively investigated. However, little is known about the role of IFIT5 in any cellular processes. In this study, we reported that both the mRNA and protein levels of IFIT5 are up-regulated in response to RNA virus infection or poly986786.cominosinic–cytidylic acid stimulation. Ectopic expression of IFIT5 could synergize IRF3- and NF-κB-mediated gene expression, whereas knockdown of IFIT5 impairs the transcription of these genes. Consistently, anti-viral responses of host cells are significantly increased or decreased in the presence or absence of IFIT5. Mechanistically, IFIT5 co-localizes partly with mitochondria and interacts with RIG-I and MAVS. Our study identified that IFIT5 is an important enhancer in innate immune response.

2014年白小姐铁算盘资料【唯一授权官网】】】】】

IFIT5 could associate with RIG-I and MAVS

全文:http://abbs.oxfordjournals.org/content/45/10/867.full.pdf+html

有关论文:

1 Broad and adaptable RNA structure recognition by the human interferon-induced tetratricopeptide repeat protein IFIT5

2 Interferon-Induced Ifit Proteins: Their Role in Viral Pathogene足球外围sis

3 Inhibition of translation by IFIT family members is determined by their ability to interact selectively with the 5'-terminal regions of cap0-, cap1- and 5' ppp-mRNAs

4 Human and Murine IFIT1 Proteins Do Not Restrict Infection of Negative-Sense RNA Viruses of the Orthomyxoviridae, Bunyaviridae, and Filoviridae Families

5 IFIT1 Differentially Interferes with Translation and Replication of Alphavirus Genomes and Promotes Induction of Type I Interferon

6 IFIT1: A dual sensor and effector molecule that detects non-2'-O methylated viral RNA and inhibits its translation

7 Interferon-Induced Protein Ifit2 Protects Mice from Infection of the Peripheral Nervous System by Vesicular Stomatitis Virus

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